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Zinman B, Bhosekar V, Busch R et al (2019) Semaglutide once weekly as add-on to SGLT-2 inhibitor therapy in type 2 diabetes (SUSTAIN 9): a randomised, placebo-controlled trial

Melatonin use is unlikely to cause serious medical problems, but caution is advised

But we don't have a lot of good-quality research into how effective it is

Beta adrenoreceptor receptor blocker treatment at baseline was included in a post hoc analysis (ANCOVA) to determine its influence on the semaglutide treatment effect in consideration of its metabolic side-effects